崔丽洁
发布人:吴波  发布时间:2017-11-10   浏览次数:10


1. 个人简介:

崔丽洁:博士,副研究员,遗传学硕士生导师。目前主要从事药用植物生物技术的研究工作,主要致力于喜树碱代谢工程的研究,在组培快繁、基因发掘、载体构建、遗传转化、功能鉴定,成分分析及代谢调控等方面具有扎实的理论基础和丰富的实践经验。


2. 主要研究方向:

[1] 植物生物技术

[2] 植物次生代谢


3. 代表性科研项目:

[1]国家自然科学基金面上项目:短小蛇根草中bHLH转录因子调控喜树碱合成的机制(2016.1-2019.12)课题负责人。

[2] 国家自然科学基金青年基金:短小蛇根草中水杨酸高效调控喜树碱合成的分子机制研究(2013.01-2015.12)课题负责人。

[3]上海市教委上海高校青年教师培养资助计划:短小蛇根草中喜树碱生物合成的诱导调控研究(2012.12- 2015.06)课题负责人


4. 代表性论文:

  1. Lijie Cui#, Xiaoling Ni#,Qian Ji, Xiaojuan Teng, Yanrui Yang,Chao Wu,David Zekria,Dasheng Zhang, Guoyin Kai*.Co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhizapumila. Scientific Reports, 2015, 5, 8227 ( SCI Journal, II, IF=5.295)

  2. LijieCui#, Fenfen Huang#, Dasheng Zhang, Pan Liao, Yuping Lin, Jie Zong, Guoyin Kai*. Transcriptome exploration for further understanding of the tropane alkaloids biosynthesis in Anisodus acutangulus. Molecular Genetics and Genomics, 2015, 290:1367-1377(SCI Journal, III, IF=2.728)

  3. Lijie Cui#, Qiang Huang #, Bin Yan, Yao Wang, Zhongying Qian, Jingxian Pan, Guoyin Kai*. Molecular Cloning and Expression Analysis of a Cu/Zn SOD Gene (BcCSD1) from Brassica campestris ssp. chinensis. Food Chemistry,2015, 186:306-311 (SCI Journal, II, IF=3.567)

  4. Lijie Cui, Yingying Guo, Ang Zhang, Guoyin Kai*.Improvement of tropane alkaloids in transgenic Anisodus acutangulusby genetic engineering. PlantaMedica 2012, 78(11):78-PB10 (SCI Journal, III, IF=2.160)

  5. Lijie Cui, Huizhen Peng, Ran Zhang, Yuhui Chen, Lingxia Zhao* and Kexuan Tang*. Recombinant hHscFv–RC-RNase protein derived from transgenic tobacco acts as a bifunctional molecular complex against hepatocellular carcinoma. BiotechnolApplBiochem 201259 (5):323-329 ( SCI Journal, III,IF=1.429)

  6. Lijie Cui, Yuhui Chen, Guoan Shen, Lingxia Zhao* and Kexuan Tang*. Expression of bioactive thymosin alpha 1 (Tα1) in marker-free transgenic lettuce (Lactuca sativa).Plant Mol Bio Rep. 2011, 29(2): 466-472 ( SCI Journal, III,IF= 2.304)

  7. Lijie Cui, Liya Lu, Jian Ye, Yongzhen Pang, Guoan Shen, Lingxia Zhao* and Kexuan Tang*. Development of functional lettuce for preventing and curing osteoporosis. Journal of Shanghai Jiao Tong University. 2009, 26(3): 465-474.

  8.  Guoyin Kai*, Chao Wu, Liyuan Gen, Liqiang Zhang, Lijie Cui, Xiaoling Ni. Biosynthesis and biotechnological production of anti-cancer drug Camptothecin. Phytochemistry Reviews. 2015. 14(3):525-529 (SCI Journal, III, IF= 2.662)

  9. Min Shi, Xuiqin Luo, Guanhua Ju, Xiaohong Yu, Xiaolong Hao, Qiang Huang, Jianbo Xiao, Lijie Cui, Guoyin Kai*. Increased accumulation of the cardio-cerebrovascular disease treatment drug tanshinone in Salvia miltiorrhiza hairy roots by the enzymes 3-hydroxy-3-methylglutaryl CoA reductase and 1-deoxy-D-xylulose 5-phosphate reductoisomerase.Funct Integr Genomics. 2014, 14(3):603-15 (SCI Journal, III,IF=2.478)

  10. Xiaolong Hao, Min Shi, Lijie Cui, Chao Xu, Yanjie Zhang, Guoyin Kai*. Effects of methyl jasmonate and salicylic acid on the tanshinone production and biosynthetic genes expression in transgenic Salvia miltiorrhiza hairy roots. BiotechnolApplBiochem 2015, 62(1): 24-31 ( SCI Journal, III,IF=1.429)

  11.  Guoyin Kai*, Shanshan Li, Wei Wang, Yang Lu, Jing Wang, Pan Liao, Lijie Cui. Molecular cloning and expression analysis of a new gene encoding 3-hydroxy-3-methylglutaryl-CoA synthase from Camptothecaacuminata. Russ J Plant Physiol. 2013, 60(1)131-138 (SCI Journal, IV, IF=0.814)

  12. Lijie Cui, Xiaolong Hao, Min Shi, Qiang Huang, Yonghong Wang, Guoyin Kai*. Biosynthesis and metabolic regulation of tanshinone in salvia miltiorrhiza.  ICNPU-2013, Bansko, Bulgaria(会议论文)

  13.  Guoyin Kai*, Qian Ji, Yang Lu, Zhongying Qian, Lijie Cui. Expression of Monsteradeliciosaagglutinin gene (mda) in tobacco confers resistance to peach-potato aphids. Integrative Biology2012, 4 (8):937- 944 (SCI Journal,II, IF=3.708)

  14.  Guoyin Kai*, Ang Zhang, Yingying Guo, Li Li, Lijie Cui,Xiuqin Luo, Cong Liu and Jianbo Xiao. Enhancing the production of tropane alkaloids in transgenic Anisodusacutangulus hairy root cultures by over-expressing tropinone reductase I and hyoscyamine-6b-hydroxylase. Mol. BioSyst., 2012, 8(11):2883-90 (SCI Journal, III, IF=3.074)

  15.  Guoyin Kai*, Qian Ji, Yang Lu, Zhongyin Qian, Lijie Cui. Expression of Monstera deliciosa agglutinin gene (mda) in tobacco confers resistance to peach-potato aphids.Integrative Biology,2012, 4 (8): 937 - 944SCI Journal,II, IF=4.439

  16. DongHui Liu, Yuliang Wang, Lijie Cui, Weiwei Ren, Xiaofen Sun and Kexuan Tang*. Overexpression of transcriptional factor ORCA3 increases the accumulation of catharanthine and vindoline in Catharanthusroseus hairy roots. Russ J Plant Physiol. 2011, 58(3):415-422 (SCI Journal, IV, IF=0.814)

  17. Weiwei Ren, Lingxia Zhao, Ling Zhang, Yueyue Wang, Lijie Cui, Yueli Tang, Xiaofen Sun, Kexuan Tang*. Molecular cloning and characterization of 4-hydroxyphenylpyruvate dioxygenase gene from Lactuca sativa. J Plant Physiol.2011, 168(10):1076-83 ( SCI Journal, III,IF=2.766)

  18. Weiwei Ren, Lingxia Zhao, Ling Zhang, Yueyue Wang, Lijie Cui, Yueli Tang, Xiaofen Sun, Kexuan Tang*. Molecular analysis of a homogentisate phytyltransferase gene from Lactuca sativa L.MolBiol Rep. 2011, 38(3):1813-1819 ( SCI Journal,IV,IF=1.893)

  19. Yuihui Chen, Aoxue Wang, Lingxia Zhao, Guoan Shen, LijieCui and Kexuan Tang*. Expression of thymosin alpha1 concatemer in transgenic tomato fruits. BiotechnolApplBiochem. 2009, 52(Pt4): 303-12 ( SCI Journal,III,IF=1.429)

  20. Yuhui Chen, Lingxia Zhao, Guoan Shen, Lijie Cui, Weiwei Ren, Hui Zhang, Hongmei Qianand Kexuan Tang*. Expression and analysis of Thymosin alpha 1 concatemer in Escherichia coli. BiotechnolApplBiochem. 2008, 49(Pt1): 51-56 (SCI Journal,III,IF=1.429)

  21. Donghui Liu, Hongbin Jin, Yuhui Chen, Lijie Cui,Weiwei Ren, Yifu Gong and Kexuan Tang*. Terpenoidindole alkaloids biosynthesis and metabolic engineering in Catharanthusroseus. Journal of Integrative Plant Biology 2007, 49(7):961-974 (SCI Journal, II, IF=3.484)

  22. Hui Zhang, Lingxia Zhao, Yuihui Chen, Lijie Cui, Weiwei Renand Kexuan Tang*. Expression of human coagulation Factor IX in transgenic tomato (Lycopersiconesculentum). BiotechnolApplBiochem. 2007, 48(Pt2):101-7 (SCI Journal, III,IF=1.429)

  23. Guoyin Kai*, Xiaojuan Teng, Lijie Cui, Shanshan Li, Qian Ji, Mu Tan. Effect of three plant hormone elicitors on the camptothecin accumulation and gene transcript profiling in Camptotheca acuminata seedlings. Interntional Journal of Science 2014 ,3(1): 86-95.

  24. Qijia Liu, Lijie Cui, YingyingGuo, Xiaoling Ni, Yan Zhang, Guoyin Kai*. Optimization of nutritive factors in culture media for growth and tropane alkaloid production from Anisodus acutangulus Hairy Roots. Journal of Applied Pharmaceutical Science 2013, 3 (01):1-4.

  25. 潘静娴张建林陈锦祥陈英杰颜彬崔丽洁开国银*.常规水稻新品系‘沪选101’的农艺性状研究上海农业学报, 2016, (4): 25-28.

  26. 肖禾王萌崔丽洁开国银潘静娴*24份普通白菜遗传多样性的形态特征和RAPD分析上海师范大学学报(自然科学版), 2015,(6):585-592, 2015/12/15.

  27. 卞莹莹颜彬崔丽洁潘静娴开国银*不结球白菜子叶离体培养与植株再生的研究.上海师范大学学报(自然科学版), 2015(6):579-584.

  28. 陈英杰,陈景祥,潘静娴,崔丽洁,颜彬,开国银*.特色水稻新品系紫叶黑粳的选育研究. 上海农业学报2015,31(2):60-64.

  29. 陈泠先,崔丽洁,钱忠英,潘静娴,开国银*.普通白菜(小白菜)遗传转化研究进展. 中国蔬菜201224):1-6.

  30. 鞠冠华,崔丽洁,张书,钱忠英,潘静娴,开国银*. 植物耐热性的分子机制研究进展. 长江蔬菜201224):5-11.

  31. 陈玉辉赵凌侠柴友荣崔丽洁董仲琦钱虹妹唐克轩*.抗黄萎病基因StVe转化番茄的研究.园艺学报2008,35(5): 693-700.

  32. 陈玉辉赵凌侠崔丽洁唐克轩*.转基因植物生产药用蛋白研究进展.中国农业科技导报2007,9(5):36-44.

  33. 刘礼仕崔丽洁张大生吴少华*. 棕包梨的RAPD分析. 福建农林大学学报2007,36(3):250-253.

  34. 张大生崔丽洁王景明吴少华*.红巴梨f3h基因的克隆及植物表达载体的构建.南京林业大学学报,2005,29(2):65-68.

  35. 孙仲序*刘静崔丽洁杨红花赵春芝.樱桃砧木叶片和叶柄再生体系的构建.生物技术2002,12(5):14-16.


5. 获奖情况:

[1] 2017荣获上海师范大学“第四届青年教师教学竞赛”自然科学应用学科组‘一等奖’;

[2]2015年荣获 《丹参等中药活性成分的代谢调控关键技术与作用机理研究》荣获上海科技进步奖‘三等奖’,排名第4

[3]2015年荣获《丹参等有效成分的生物合成及调控机制研究》荣获第五届上海中医药科技奖‘三等奖’,排名第4

[4] 2015荣获上海师范大学生环学院“第一届青年教师大奖赛”三等奖.



更新于2017年11月